Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis

Since it is unknown whether thyroid hormones (THs) regulate mitochondrial function in human epidermis, we treated organ-cultured human skin, or isolated cultured human epidermal keratinocytes, with triiodothyronine (100 pmol/L) or thyroxine (100 nmol/L). Both THs significantly increased protein expr...

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Veröffentlicht in:	Journal of investigative dermatology 2016-10, Vol.136 (10), p.2003-2012
Hauptverfasser:	Vidali, Silvia, Chéret, Jérémy, Giesen, Melanie, Haeger, Swantje, Alam, Majid, Watson, Rachel E.B., Langton, Abigail K., Klinger, Matthias, Knuever, Jana, Funk, Wolfgang, Kofler, Barbara, Paus, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Cells, Cultured Down-Regulation - drug effects Epidermis - drug effects Epidermis - metabolism Humans Keratinocytes - drug effects Keratinocytes - metabolism Matrix Metalloproteinases - metabolism Mitochondria - drug effects Mitochondria - metabolism Organ Culture Techniques Reactive Oxygen Species - metabolism Skin Aging - physiology Skin Diseases - drug therapy Skin Diseases - pathology Thyroxine - administration & dosage Thyroxine - pharmacology Triiodothyronine - administration & dosage Triiodothyronine - pharmacology
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