Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides

Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides

Three new natural products, corallocins A–C (1–3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2016-09, Vol.79 (9), p.2264-2269
Hauptverfasser: Wittstein, Kathrin, Rascher, Monique, Rupcic, Zeljka, Löwen, Eduard, Winter, Barbara, Köster, Reinhard W, Stadler, Marc
Format: Artikel
Sprache:eng
Schlagworte:
Agaricales - chemistry
Animals
Astrocytes - drug effects
Benzofurans - chemistry
Benzofurans - isolation & purification
Benzofurans - pharmacology
Brain-Derived Neurotrophic Factor - agonists
Germany
Humans
Molecular Structure
Nerve Growth Factors - agonists
Nerve Tissue Proteins
Nuclear Magnetic Resonance, Biomolecular
PC12 Cells
Rats
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Zusammenfassung:Three new natural products, corallocins A–C (1–3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.6b00371