Design, Optimization, and Evaluation of Lurasidone Hydrochloride Nanocrystals

The present investigation was carried out to design, optimize, and evaluate lurasidone hydrochloride nanocrystals for improving its solubility and dissolution characteristics. Nanocrystals were prepared by media milling technique using zirconium oxide beads with 0.1 mm diameter. Various stabilizers,...

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Veröffentlicht in:	AAPS PharmSciTech 2016-10, Vol.17 (5), p.1150-1158
Hauptverfasser:	Shah, Sunny, Parmar, Bhavin, Soniwala, Moinuddin, Chavda, Jayant
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Calorimetry, Differential Scanning - methods Chemistry, Pharmaceutical - methods Freeze Drying Lurasidone Hydrochloride - chemistry Nanoparticles - chemistry Particle Size Pharmacology/Toxicology Pharmacy Powders - chemistry Research Article Solubility X-Ray Diffraction - methods
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Beschreibung
Zusammenfassung:	The present investigation was carried out to design, optimize, and evaluate lurasidone hydrochloride nanocrystals for improving its solubility and dissolution characteristics. Nanocrystals were prepared by media milling technique using zirconium oxide beads with 0.1 mm diameter. Various stabilizers, viz. poloxamer 188, PVP K30, SLS, HPMC E15, and PVP S 630 D, were evaluated to stabilize the nanocrystals. The Pareto chart obtained through Plackett-Burman screening design revealed that HPMC E 15 showed the highest standardized effect ( p value
ISSN:	1530-9932 1530-9932
DOI:	10.1208/s12249-015-0449-z