Effect of genotoxic exposure to chromium among electroplating workers in Taiwan

The objective of this study was to investigate the association between chromium (Cr) concentrations and sister chromatid exchanges (SCE) formation in Cr workers and to assess the effects of susceptible genes (glutathione S-transferase M1 and T1) on the frequency of deletion and SCE/cell. Urinary Cr...

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Veröffentlicht in:	The Science of the total environment 2001-11, Vol.279 (1), p.21-28
Hauptverfasser:	Wu, Fang-Yang, Wu, Wu-Yui, Kuo, Hsien-Wen, Liu, Chiu-Shong, Wang, Ruey-Yun, Lai, Jim-Shoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chromium - adverse effects Cromium worker DNA Damage Genotype Glutathione Transferase - genetics GSTM1 GSTT1 HFC Humans Male Medical sciences Metals and various inorganic compounds Middle Aged Occupational Exposure Polymerase Chain Reaction Risk Factors SCE Sister Chromatid Exchange - genetics Smoking SOD Toxicology
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Beschreibung
Zusammenfassung:	The objective of this study was to investigate the association between chromium (Cr) concentrations and sister chromatid exchanges (SCE) formation in Cr workers and to assess the effects of susceptible genes (glutathione S-transferase M1 and T1) on the frequency of deletion and SCE/cell. Urinary Cr concentration was significantly elevated in Cr workers (3.67±3.89 μg/g creatinine) compared to control group (1.21±1.16 μg/g creatinine, P
ISSN:	0048-9697 1879-1026
DOI:	10.1016/S0048-9697(01)00685-4