Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis

It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptib...

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Veröffentlicht in:	Annals of clinical and laboratory science 2016-09, Vol.46 (5), p.470-473
Hauptverfasser:	Su, Song-Sen, Wang, Su-Li, Lu, Liang-Jing, Lin, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Case-Control Studies Cohort Studies Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Male Odds Ratio Polymorphism, Single Nucleotide - genetics Receptors, Interleukin - genetics Spondylitis, Ankylosing - genetics
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Zusammenfassung:	It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population. A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped. None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population. The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.
ISSN:	1550-8080