Immunohematotoxicity studies with combinations of dapsone and zidovudine

We investigated the immunohematoxicities of the antiparasitic drug dapsone (DDS) and the antiretroviral drug zidovudine (ZDV, AZT) given alone or in combination in BALB/c mice. DDS is used for prophylaxis and treatment of Pneumocystis carinii infection in AIDS patients. We examined the impact of con...

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Veröffentlicht in:	International immunopharmacology 2001-11, Vol.1 (12), p.2131-2141
Hauptverfasser:	Freund, Yvonne R, Dousman, Linda, Riccio, Edward S, Sato, Barbara, MacGregor, James T, Mohagheghpour, Nahid
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-Related Opportunistic Infections - prevention & control Anemia - chemically induced Animals Anti-HIV Agents - administration & dosage Anti-HIV Agents - toxicity antiparasitic agents antiprotozoal agents Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - toxicity AZT Biological and medical sciences Bone Marrow - drug effects Combination therapy Concanavalin A - pharmacology Dapsone Dapsone - administration & dosage Dapsone - analogs & derivatives Dapsone - blood Dapsone - toxicity DDS Dose-Response Relationship, Drug Drug Interactions Drug toxicity and drugs side effects treatment Female Hematotoxicity Leukopenia - chemically induced Lymph Nodes - drug effects Lymphocyte Activation - drug effects Medical sciences Methemoglobinemia - chemically induced Mice Mice, Inbred BALB C Neutropenia - chemically induced Pharmacology. Drug treatments Pneumocystis carinii Pneumonia, Pneumocystis - prevention & control Thrombocytosis - chemically induced Thymus Gland - drug effects Toxicity: blood ZDV Zidovudine Zidovudine - administration & dosage Zidovudine - toxicity
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Zusammenfassung:	We investigated the immunohematoxicities of the antiparasitic drug dapsone (DDS) and the antiretroviral drug zidovudine (ZDV, AZT) given alone or in combination in BALB/c mice. DDS is used for prophylaxis and treatment of Pneumocystis carinii infection in AIDS patients. We examined the impact of concurrent administration of these drugs on the immune and hematopoietic systems because DDS causes hematotoxicity and ZDV therapy results in bone marrow toxicity. Daily oral administration of DDS at 25 and 50 mg/kg for 28 days caused a slight anemia, marked methemoglobinemia, reticulocytosis, and a moderate leukopenia ( P
ISSN:	1567-5769 1878-1705
DOI:	10.1016/S1567-5769(01)00138-2