Repeated Measurements of Hepatitis B Surface Antigen Identify Carriers of Inactive HBV During Long-term Follow-up

Background & Aims Measurements of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA might help to identify carriers of inactive HBV. We assessed the performance of repeated measurements of HBsAg over a median time period of 8 years. Methods We performed a retrospective study of...

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Veröffentlicht in:	Clinical gastroenterology and hepatology 2016-10, Vol.14 (10), p.1481-1489.e5
Hauptverfasser:	Brouwer, Willem P, Lik-Yuen Chan, Henry, Brunetto, Maurizia R, Martinot-Peignoux, Michelle, Arends, Pauline, Cornberg, Markus, Cherubini, Beatrice, Thompson, Alex J.V, Liaw, Yun-Fan, Marcellin, Patrick, Janssen, Harry L.A, Hansen, Bettina E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alanine Transaminase - blood Asia Australia Carrier State - diagnosis Diagnostic Tests, Routine - methods DNA, Viral - blood Dynamic Prediction Europe Female Gastroenterology and Hepatology HBe Antigen HBs Antigen Hepatitis B Surface Antigens - blood Hepatitis B, Chronic - diagnosis Humans Inactive Carrier Longitudinal Studies Male Middle Aged Outpatients Retrospective Studies Sensitivity and Specificity Tertiary Care Centers
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Zusammenfassung:	Background & Aims Measurements of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA might help to identify carriers of inactive HBV. We assessed the performance of repeated measurements of HBsAg over a median time period of 8 years. Methods We performed a retrospective study of 292 HBe antigen–negative patients with chronic HBV infection, normal levels of alanine aminotransferase (ALT), levels of HBV DNA 100 IU/mL had HBV activity in the third year. The combination of HBsAg level
ISSN:	1542-3565 1542-7714
DOI:	10.1016/j.cgh.2016.01.019