Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans
This study tested the hypothesis that watermelon juice supplementation would improve nitric oxide bioavailability and exercise performance. Eight healthy recreationally-active adult males reported to the laboratory on two occasions for initial testing without dietary supplementation (control conditi...
Gespeichert in:
| Veröffentlicht in: | Nitric oxide 2016-09, Vol.59, p.10-20 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20 |
|---|---|
| container_issue | |
| container_start_page | 10 |
| container_title | Nitric oxide |
| container_volume | 59 |
| creator | Bailey, Stephen J. Blackwell, Jamie R. Williams, Ewan Vanhatalo, Anni Wylie, Lee J. Winyard, Paul G. Jones, Andrew M. |
| description | This study tested the hypothesis that watermelon juice supplementation would improve nitric oxide bioavailability and exercise performance. Eight healthy recreationally-active adult males reported to the laboratory on two occasions for initial testing without dietary supplementation (control condition). Thereafter, participants were randomly assigned, in a cross-over experimental design, to receive 16 days of supplementation with 300 mL·day−1 of a watermelon juice concentrate, which provided ∼3.4 g l-citrulline·day−1 and an apple juice concentrate as a placebo. Participants reported to the laboratory on days 14 and 16 of supplementation to assess the effects of the interventions on blood pressure, plasma [l-citrulline], plasma [l-arginine], plasma [nitrite], muscle oxygenation and time-to-exhaustion during severe-intensity exercise. Compared to control and placebo, plasma [l-citrulline] (29 ± 4, 22 ± 6 and 101 ± 23 μM), [l-arginine] (74 ± 9, 67 ± 13 and 116 ± 9 μM) and [nitrite] (102 ± 29, 106 ± 21 and 201 ± 106 nM) were higher after watermelon juice supplementation (P |
| doi_str_mv | 10.1016/j.niox.2016.06.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1821789704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1089860316300830</els_id><sourcerecordid>1821789704</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-6eac65be5a8f4df85b4ec9ed0b51f965d7c0f4ef46c22ac949ac504c8803cf383</originalsourceid><addsrcrecordid>eNp9kE1rGzEQhkVJaRK3f6CHomMudkf7qYVeSkibQKCX9Cy02hEdd1faSlrbufeHR47THAsDehlePTAPYx8FbASI5vN248gfNkXOG8gD8g27ECC7tWyEOHvNUJ6zyxi3AFCVsnnHzou2bGUpigv292Hv-R7xd-Te8r1OGCYcvePbhQzyuMzziBO6pBPlLU1z8DuM3FEKZLg_0IC8J693mkbd00jpkfdL4s4njm5YgnaZgwcMhiLyGYP1YXpekuO_lhzje_bW6jHih5d3xX5-u3m4vl3f__h-d_31fm0qgLRuUJum7rHW0laDlXVfoelwgL4WtmvqoTVgK7RVY4pCm67qtKmhMlJCaWwpyxW7OnHzEX8WjElNFA2Oo3bol6iELEQruzZrWrHiVDXBxxjQqjnQpMOjEqCO9tVWHe2ro30FeeDI__TCX_oJh9cv_3TnwpdTAfOVO8KgoiHMLgYKaJIaPP2P_wSdRJsB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1821789704</pqid></control><display><type>article</type><title>Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Bailey, Stephen J. ; Blackwell, Jamie R. ; Williams, Ewan ; Vanhatalo, Anni ; Wylie, Lee J. ; Winyard, Paul G. ; Jones, Andrew M.</creator><creatorcontrib>Bailey, Stephen J. ; Blackwell, Jamie R. ; Williams, Ewan ; Vanhatalo, Anni ; Wylie, Lee J. ; Winyard, Paul G. ; Jones, Andrew M.</creatorcontrib><description>This study tested the hypothesis that watermelon juice supplementation would improve nitric oxide bioavailability and exercise performance. Eight healthy recreationally-active adult males reported to the laboratory on two occasions for initial testing without dietary supplementation (control condition). Thereafter, participants were randomly assigned, in a cross-over experimental design, to receive 16 days of supplementation with 300 mL·day−1 of a watermelon juice concentrate, which provided ∼3.4 g l-citrulline·day−1 and an apple juice concentrate as a placebo. Participants reported to the laboratory on days 14 and 16 of supplementation to assess the effects of the interventions on blood pressure, plasma [l-citrulline], plasma [l-arginine], plasma [nitrite], muscle oxygenation and time-to-exhaustion during severe-intensity exercise. Compared to control and placebo, plasma [l-citrulline] (29 ± 4, 22 ± 6 and 101 ± 23 μM), [l-arginine] (74 ± 9, 67 ± 13 and 116 ± 9 μM) and [nitrite] (102 ± 29, 106 ± 21 and 201 ± 106 nM) were higher after watermelon juice supplementation (P < 0.01). However, systolic blood pressure was higher in the watermelon juice (130 ± 11) and placebo (131 ± 9) conditions compared to the control condition (124 ± 8 mmHg; P < 0.05). The skeletal muscle oxygenation index during moderate-intensity exercise was greater in the watermelon juice condition than the placebo and control conditions (P < 0.05), but time-to-exhaustion during the severe-intensity exercise test (control: 478 ± 80, placebo: 539 ± 108, watermelon juice: 550 ± 143 s) was not significantly different between conditions (P < 0.05). In conclusion, while watermelon juice supplementation increased baseline plasma [nitrite] and improved muscle oxygenation during moderate-intensity exercise, it increased resting blood pressure and did not improve time-to-exhaustion during severe-intensity exercise. These findings do not support the use of watermelon juice supplementation as a nutritional intervention to lower blood pressure or improve endurance exercise performance in healthy adults.</description><identifier>ISSN: 1089-8603</identifier><identifier>EISSN: 1089-8611</identifier><identifier>DOI: 10.1016/j.niox.2016.06.008</identifier><identifier>PMID: 27378312</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arginine - blood ; Arterial Pressure ; Blood Glucose - analysis ; Blood pressure ; Citrulline - blood ; Citrullus ; Dietary Supplements ; Fatigue ; Fruit and Vegetable Juices ; Heart Rate ; Humans ; l-arginine ; Lactic Acid - blood ; Male ; Malus ; Metabolism ; Muscle oxygenation ; Nitric oxide ; Nitric Oxide - analysis ; Nitrites - blood ; Oxygen Consumption ; Physical Endurance ; Pulmonary Gas Exchange ; Young Adult</subject><ispartof>Nitric oxide, 2016-09, Vol.59, p.10-20</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-6eac65be5a8f4df85b4ec9ed0b51f965d7c0f4ef46c22ac949ac504c8803cf383</citedby><cites>FETCH-LOGICAL-c400t-6eac65be5a8f4df85b4ec9ed0b51f965d7c0f4ef46c22ac949ac504c8803cf383</cites><orcidid>0000-0003-2546-5667 ; 0000-0002-9613-1202</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.niox.2016.06.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27378312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bailey, Stephen J.</creatorcontrib><creatorcontrib>Blackwell, Jamie R.</creatorcontrib><creatorcontrib>Williams, Ewan</creatorcontrib><creatorcontrib>Vanhatalo, Anni</creatorcontrib><creatorcontrib>Wylie, Lee J.</creatorcontrib><creatorcontrib>Winyard, Paul G.</creatorcontrib><creatorcontrib>Jones, Andrew M.</creatorcontrib><title>Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans</title><title>Nitric oxide</title><addtitle>Nitric Oxide</addtitle><description>This study tested the hypothesis that watermelon juice supplementation would improve nitric oxide bioavailability and exercise performance. Eight healthy recreationally-active adult males reported to the laboratory on two occasions for initial testing without dietary supplementation (control condition). Thereafter, participants were randomly assigned, in a cross-over experimental design, to receive 16 days of supplementation with 300 mL·day−1 of a watermelon juice concentrate, which provided ∼3.4 g l-citrulline·day−1 and an apple juice concentrate as a placebo. Participants reported to the laboratory on days 14 and 16 of supplementation to assess the effects of the interventions on blood pressure, plasma [l-citrulline], plasma [l-arginine], plasma [nitrite], muscle oxygenation and time-to-exhaustion during severe-intensity exercise. Compared to control and placebo, plasma [l-citrulline] (29 ± 4, 22 ± 6 and 101 ± 23 μM), [l-arginine] (74 ± 9, 67 ± 13 and 116 ± 9 μM) and [nitrite] (102 ± 29, 106 ± 21 and 201 ± 106 nM) were higher after watermelon juice supplementation (P < 0.01). However, systolic blood pressure was higher in the watermelon juice (130 ± 11) and placebo (131 ± 9) conditions compared to the control condition (124 ± 8 mmHg; P < 0.05). The skeletal muscle oxygenation index during moderate-intensity exercise was greater in the watermelon juice condition than the placebo and control conditions (P < 0.05), but time-to-exhaustion during the severe-intensity exercise test (control: 478 ± 80, placebo: 539 ± 108, watermelon juice: 550 ± 143 s) was not significantly different between conditions (P < 0.05). In conclusion, while watermelon juice supplementation increased baseline plasma [nitrite] and improved muscle oxygenation during moderate-intensity exercise, it increased resting blood pressure and did not improve time-to-exhaustion during severe-intensity exercise. These findings do not support the use of watermelon juice supplementation as a nutritional intervention to lower blood pressure or improve endurance exercise performance in healthy adults.</description><subject>Arginine - blood</subject><subject>Arterial Pressure</subject><subject>Blood Glucose - analysis</subject><subject>Blood pressure</subject><subject>Citrulline - blood</subject><subject>Citrullus</subject><subject>Dietary Supplements</subject><subject>Fatigue</subject><subject>Fruit and Vegetable Juices</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>l-arginine</subject><subject>Lactic Acid - blood</subject><subject>Male</subject><subject>Malus</subject><subject>Metabolism</subject><subject>Muscle oxygenation</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>Nitrites - blood</subject><subject>Oxygen Consumption</subject><subject>Physical Endurance</subject><subject>Pulmonary Gas Exchange</subject><subject>Young Adult</subject><issn>1089-8603</issn><issn>1089-8611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJaRK3f6CHomMudkf7qYVeSkibQKCX9Cy02hEdd1faSlrbufeHR47THAsDehlePTAPYx8FbASI5vN248gfNkXOG8gD8g27ECC7tWyEOHvNUJ6zyxi3AFCVsnnHzou2bGUpigv292Hv-R7xd-Te8r1OGCYcvePbhQzyuMzziBO6pBPlLU1z8DuM3FEKZLg_0IC8J693mkbd00jpkfdL4s4njm5YgnaZgwcMhiLyGYP1YXpekuO_lhzje_bW6jHih5d3xX5-u3m4vl3f__h-d_31fm0qgLRuUJum7rHW0laDlXVfoelwgL4WtmvqoTVgK7RVY4pCm67qtKmhMlJCaWwpyxW7OnHzEX8WjElNFA2Oo3bol6iELEQruzZrWrHiVDXBxxjQqjnQpMOjEqCO9tVWHe2ro30FeeDI__TCX_oJh9cv_3TnwpdTAfOVO8KgoiHMLgYKaJIaPP2P_wSdRJsB</recordid><startdate>20160930</startdate><enddate>20160930</enddate><creator>Bailey, Stephen J.</creator><creator>Blackwell, Jamie R.</creator><creator>Williams, Ewan</creator><creator>Vanhatalo, Anni</creator><creator>Wylie, Lee J.</creator><creator>Winyard, Paul G.</creator><creator>Jones, Andrew M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2546-5667</orcidid><orcidid>https://orcid.org/0000-0002-9613-1202</orcidid></search><sort><creationdate>20160930</creationdate><title>Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans</title><author>Bailey, Stephen J. ; Blackwell, Jamie R. ; Williams, Ewan ; Vanhatalo, Anni ; Wylie, Lee J. ; Winyard, Paul G. ; Jones, Andrew M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-6eac65be5a8f4df85b4ec9ed0b51f965d7c0f4ef46c22ac949ac504c8803cf383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Arginine - blood</topic><topic>Arterial Pressure</topic><topic>Blood Glucose - analysis</topic><topic>Blood pressure</topic><topic>Citrulline - blood</topic><topic>Citrullus</topic><topic>Dietary Supplements</topic><topic>Fatigue</topic><topic>Fruit and Vegetable Juices</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>l-arginine</topic><topic>Lactic Acid - blood</topic><topic>Male</topic><topic>Malus</topic><topic>Metabolism</topic><topic>Muscle oxygenation</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>Nitrites - blood</topic><topic>Oxygen Consumption</topic><topic>Physical Endurance</topic><topic>Pulmonary Gas Exchange</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bailey, Stephen J.</creatorcontrib><creatorcontrib>Blackwell, Jamie R.</creatorcontrib><creatorcontrib>Williams, Ewan</creatorcontrib><creatorcontrib>Vanhatalo, Anni</creatorcontrib><creatorcontrib>Wylie, Lee J.</creatorcontrib><creatorcontrib>Winyard, Paul G.</creatorcontrib><creatorcontrib>Jones, Andrew M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nitric oxide</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bailey, Stephen J.</au><au>Blackwell, Jamie R.</au><au>Williams, Ewan</au><au>Vanhatalo, Anni</au><au>Wylie, Lee J.</au><au>Winyard, Paul G.</au><au>Jones, Andrew M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans</atitle><jtitle>Nitric oxide</jtitle><addtitle>Nitric Oxide</addtitle><date>2016-09-30</date><risdate>2016</risdate><volume>59</volume><spage>10</spage><epage>20</epage><pages>10-20</pages><issn>1089-8603</issn><eissn>1089-8611</eissn><abstract>This study tested the hypothesis that watermelon juice supplementation would improve nitric oxide bioavailability and exercise performance. Eight healthy recreationally-active adult males reported to the laboratory on two occasions for initial testing without dietary supplementation (control condition). Thereafter, participants were randomly assigned, in a cross-over experimental design, to receive 16 days of supplementation with 300 mL·day−1 of a watermelon juice concentrate, which provided ∼3.4 g l-citrulline·day−1 and an apple juice concentrate as a placebo. Participants reported to the laboratory on days 14 and 16 of supplementation to assess the effects of the interventions on blood pressure, plasma [l-citrulline], plasma [l-arginine], plasma [nitrite], muscle oxygenation and time-to-exhaustion during severe-intensity exercise. Compared to control and placebo, plasma [l-citrulline] (29 ± 4, 22 ± 6 and 101 ± 23 μM), [l-arginine] (74 ± 9, 67 ± 13 and 116 ± 9 μM) and [nitrite] (102 ± 29, 106 ± 21 and 201 ± 106 nM) were higher after watermelon juice supplementation (P < 0.01). However, systolic blood pressure was higher in the watermelon juice (130 ± 11) and placebo (131 ± 9) conditions compared to the control condition (124 ± 8 mmHg; P < 0.05). The skeletal muscle oxygenation index during moderate-intensity exercise was greater in the watermelon juice condition than the placebo and control conditions (P < 0.05), but time-to-exhaustion during the severe-intensity exercise test (control: 478 ± 80, placebo: 539 ± 108, watermelon juice: 550 ± 143 s) was not significantly different between conditions (P < 0.05). In conclusion, while watermelon juice supplementation increased baseline plasma [nitrite] and improved muscle oxygenation during moderate-intensity exercise, it increased resting blood pressure and did not improve time-to-exhaustion during severe-intensity exercise. These findings do not support the use of watermelon juice supplementation as a nutritional intervention to lower blood pressure or improve endurance exercise performance in healthy adults.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27378312</pmid><doi>10.1016/j.niox.2016.06.008</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2546-5667</orcidid><orcidid>https://orcid.org/0000-0002-9613-1202</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1089-8603 |
| ispartof | Nitric oxide, 2016-09, Vol.59, p.10-20 |
| issn | 1089-8603 1089-8611 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1821789704 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Arginine - blood Arterial Pressure Blood Glucose - analysis Blood pressure Citrulline - blood Citrullus Dietary Supplements Fatigue Fruit and Vegetable Juices Heart Rate Humans l-arginine Lactic Acid - blood Male Malus Metabolism Muscle oxygenation Nitric oxide Nitric Oxide - analysis Nitrites - blood Oxygen Consumption Physical Endurance Pulmonary Gas Exchange Young Adult |
| title | Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A08%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20weeks%20of%20watermelon%20juice%20supplementation%20improves%20nitric%20oxide%20bioavailability%20but%20not%20endurance%20exercise%20performance%20in%20humans&rft.jtitle=Nitric%20oxide&rft.au=Bailey,%20Stephen%20J.&rft.date=2016-09-30&rft.volume=59&rft.spage=10&rft.epage=20&rft.pages=10-20&rft.issn=1089-8603&rft.eissn=1089-8611&rft_id=info:doi/10.1016/j.niox.2016.06.008&rft_dat=%3Cproquest_cross%3E1821789704%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1821789704&rft_id=info:pmid/27378312&rft_els_id=S1089860316300830&rfr_iscdi=true |