Brain Invasion in meningiomas: Incidence and correlations with clinical variables and prognosis

Abstract Objective In meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial. Methods Correlation of brain invasion with clinical and histopathological variables was investigated in 467 patients with primary intracranial meningioma. Results Diffuse (N=3, 10%), cluster- (N=11, 34%) or finger-like (N=18, 56%) invasion was detected in 32 patients (7%). Brain invasion was more common in males than in females (13% vs. 5%; OR: 2.75, 95%CI 1.29-5.89; p=.009) and pattern of invasion differed between genders (p=.037). Brain invasion was absent in 401 benign, present in 48% of 60 atypical (N=29) and 50% of 6 anaplastic (N=3) meningiomas (p