Amine Activation: Synthesis of N‑(Hetero)arylamides from Isothioureas and Carboxylic Acids

Amine Activation: Synthesis of N‑(Hetero)arylamides from Isothioureas and Carboxylic Acids

A novel method for N-(hetero)­arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challengin...

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Veröffentlicht in:Organic letters 2016-09, Vol.18 (18), p.4602-4605
Hauptverfasser: Zhu, Yan-Ping, Sergeyev, Sergey, Franck, Philippe, Orru, Romano V. A, Maes, Bert U. W
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel method for N-(hetero)­arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b02247