Palladium-Catalyzed Ortho-Selective C–H Oxidative Carbonylation of N‑Substituted Anilines with CO and Primary Amines for the Synthesis of o‑Aminobenzamides

An efficient, one-pot strategy with high selectivity and high atom economy for the synthesis of o-aminobenzamides has been developed via palladium-catalyzed ortho-selective C–H oxidative carbonylation of N-substituted anilines with CO and primary amines. A wide range of N-substituted anilines and primary amines can be tolerated in this transformation to afford the corresponding o-aminobenzamides in moderate to excellent yields under mild conditions.