Expression and localization of angiopoietin family in buffalo ovarian follicles during different stages of development and modulatory role of angiopoietins on steroidogenesis and survival of cultured buffalo granulosa cells

The present study investigated the expression and localization of angiopoietin (ANPT) family members in buffalo ovarian follicles of different size. It also looked at the role of ANPTs in estradiol secretion and mRNA expression of phosphoinositide-3-kinase–protein kinase B signaling pathway cellular...

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Veröffentlicht in:	Theriogenology 2016-10, Vol.86 (7), p.1818-1833
Hauptverfasser:	Mishra, S.R., Thakur, N., Somal, A., Parmar, M.S., Yadav, V.P., Bharati, Jaya, Bharti, M.K., Paul, A., Verma, M.R., Chouhan, V.S., Sharma, G. Taru, Singh, G., González, L.A., D'Occhio, M.J., Sarkar, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin Angiopoietins - genetics Angiopoietins - metabolism Animals Buffalo Buffaloes - physiology Cells, Cultured Estradiol Estradiol - metabolism Female Follicle Gene Expression Regulation - physiology Granulosa Cells - physiology Growth factor Ovarian Follicle - metabolism Progesterone - metabolism Protein Transport - physiology
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Zusammenfassung:	The present study investigated the expression and localization of angiopoietin (ANPT) family members in buffalo ovarian follicles of different size. It also looked at the role of ANPTs in estradiol secretion and mRNA expression of phosphoinositide-3-kinase–protein kinase B signaling pathway cellular proliferation (phosphoinositide-dependant kinase and protein kinase B [AKT]) and proapoptotic (BAD) factors with caspase 3 in cultured buffalo granulosa cells (GCs). The mRNA and protein expression of ANPT-1 was greatest (P
ISSN:	0093-691X 1879-3231
DOI:	10.1016/j.theriogenology.2016.05.033