Roles of phospholipid signaling in chemoattractant-induced responses

Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cell science 2000-09, Vol.113 ( Pt 17) (17), p.2935-2940
Hauptverfasser:	Wu, D, Huang, C K, Jiang, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemokines - physiology Chemotactic Factors - physiology Chemotaxis GTP-Binding Proteins - metabolism Mice Mice, Knockout Models, Biological Neutrophils - metabolism Neutrophils - physiology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - physiology phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphatidylinositol Phosphates - metabolism Signal Transduction Superoxides - metabolism Type C Phospholipases - genetics Type C Phospholipases - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K). Recent studies of mouse lines that lack PLC-(beta)2, PLC-(beta)3, or PI3K(gamma) demonstrate that chemoattractants act through PLC-(beta)2 and PLC-(beta)3 to hydrolyze PtdIns(4,5)P(2) and through PI3K(gamma) to phosphorylate PtdIns(4,5)P(2) in mouse neutrophils. These studies also confirmed the importance and revealed new roles of these signaling pathways in chemoattractant-induced responses.
ISSN:	0021-9533 1477-9137
DOI:	10.1242/jcs.113.17.2935