A novel RHCE02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens

A novel RHCE02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens

We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti‐C and anti‐e and antigen strength was markedly weakened. We believe that these chang...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transfusion (Philadelphia, Pa.) Pa.), 2016-09, Vol.56 (9), p.2391-2392
Hauptverfasser: Hellberg, Åsa, Pesjak, Emma, Karlsson, Jessica, Storry, Jill R.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Antibodies, Monoclonal - immunology
Antigens
Blood & organ donations
Blood Donors
Erythrocytes - immunology
Erythrocytes - metabolism
Genotype
Haplotypes - genetics
Hepatitis B Core Antigens - immunology
Hepatitis B e Antigens - immunology
Humans
Phenotype
Rh-Hr Blood-Group System - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti‐C and anti‐e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.13679