Biomarker response in Sheim (Acanthopagrus latus) exposed to polycyclic aromatic hydrocarbons

Adult sheim Acanthopagrus latus, a fish specie native to the Arabian Gulf, were exposed to benzo(a)pyrene (BaP) dissolved in dimethyl sulfoxide, and effects on cytochrome P4501A were examined. The activity of ethoxyresorufin O-deethylase in liver microsomes increased with increasing BaP exposure con...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 2001-08, Vol.67 (2), p.210-216
Hauptverfasser:	BEG, M. U, AL-BAHLOUL, M, JACOB, P. G, BEG, K. R, AL-MATROUK, K, ABDEL-ELAH, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthopagrus latus Animal, plant and microbial ecology Animals Applied ecology Arabia Biological and medical sciences Biomarkers Cytochrome P-450 CYP1A1 - metabolism cytochrome P4501A Ecotoxicology, biological effects of pollution Fishes Fundamental and applied biological sciences. Psychology Marine and brackish environment Marine Biology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Petroleum Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - toxicity Water Pollutants, Chemical - toxicity
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Zusammenfassung:	Adult sheim Acanthopagrus latus, a fish specie native to the Arabian Gulf, were exposed to benzo(a)pyrene (BaP) dissolved in dimethyl sulfoxide, and effects on cytochrome P4501A were examined. The activity of ethoxyresorufin O-deethylase in liver microsomes increased with increasing BaP exposure concentration, and enzyme activity induction was maximized on the fourth day of exposure and then declined. Use of the specie as a biological indicator of PAH contamination in the waters of the Arabian Gulf region is discussed briefly.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/s001280112