A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients

Artemether is co-administered with lumefantrine as part of a fixed-dose combination therapy for malaria in both adult and pediatric patients. However, artemether exposure is higher in younger infants (1-3 months) with a lower body weight (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2016-10, Vol.105 (10), p.3205-3213
Hauptverfasser:	Lin, Wen, Heimbach, Tycho, Jain, Jay Prakash, Awasthi, Rakesh, Hamed, Kamal, Sunkara, Gangadhar, He, Handan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Antimalarials - blood Antimalarials - pharmacokinetics Artemisinins - blood Artemisinins - pharmacokinetics Child Child, Preschool clinical pharmacokinetics CYP enzymes drug metabolizing enzymes elimination Female hepatic clearance Humans Infant interspecies scaling Male Middle Aged Models, Biological physiologically based pharmacokinetic modeling preclinical pharmacokinetics simulations Young Adult
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Beschreibung
Zusammenfassung:	Artemether is co-administered with lumefantrine as part of a fixed-dose combination therapy for malaria in both adult and pediatric patients. However, artemether exposure is higher in younger infants (1-3 months) with a lower body weight (
ISSN:	0022-3549 1520-6017
DOI:	10.1016/j.xphs.2016.06.026