Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis

Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis

Intracellular Cyt c release profiles in living human neuroblastoma undergoing amyloid β oligomer (AβO)-induced apoptosis, as a model Alzheimer's disease-associated pathogenic molecule, were analysed in a real-time manner using plasmon resonance energy transfer (PRET)-based spectroscopy.

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Veröffentlicht in:Nanoscale 2015-06, Vol.7 (23), p.10340-10343
Hauptverfasser: Lee, Jae Young, Park, Younggeun, Pun, San, Lee, Sung Sik, Lo, Joe F, Lee, Luke P
Format: Artikel
Sprache:eng
Schlagworte:
Amyloid beta-Peptides - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Cell Line
Computer Systems
Cytochromes c - metabolism
Energy transfer
Fluorescence Resonance Energy Transfer - methods
Human
Humans
Molecular Imaging - methods
Nanostructure
Neurons - cytology
Neurons - drug effects
Neurons - secretion
Oligomers
Plasmons
Real time
Spectroscopy
Surface Plasmon Resonance - methods
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Beschreibung
Zusammenfassung:Intracellular Cyt c release profiles in living human neuroblastoma undergoing amyloid β oligomer (AβO)-induced apoptosis, as a model Alzheimer's disease-associated pathogenic molecule, were analysed in a real-time manner using plasmon resonance energy transfer (PRET)-based spectroscopy.
ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr02390d