Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers

Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (58), p.11611-11614
Hauptverfasser:	Sahariah, Priyanka, Sørensen, Kasper K, Hjálmarsdóttir, Martha Á, Sigurjónsson, Ólafur E, Jensen, Knud J, Másson, Már, Thygesen, Mikkel B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Chitosan Chitosan - chemistry Chitosan - pharmacology Conjugates Enterococcus faecalis - drug effects Enterococcus faecalis - growth & development Erythrocytes - drug effects Escherichia coli - drug effects Escherichia coli - growth & development Grafting Hemolysis - drug effects Humans Microbial Sensitivity Tests Organosilicon Compounds - chemistry Peptides Polymers Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Strategy Toxicity Wasp Venoms - chemistry Wasp Venoms - pharmacology
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Zusammenfassung:	Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc04010h