Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy

Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (49), p.9995-9998
Hauptverfasser:	Saravanakumar, Gurusamy, Lee, Junseok, Kim, Jihoon, Kim, Won Jong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Bearing Biocompatibility Biocompatible Materials - chemistry Block copolymers Cell Line, Tumor Disassembly Dismantling Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Drug Design Drug Liberation Drugs Humans Hydrophobic and Hydrophilic Interactions Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - radiation effects Lactones - chemistry Light Micelles Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Polyethylene Glycols - chemistry Singlet Oxygen - metabolism Sulfides - chemistry
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Zusammenfassung:	Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc01937k