Hepatic Fibrosis Assessment Using Fractal Analysis as a Histological Grading Method
The histopathologic examination of hepatic fibrosis remains the gold standard in routine diagnosis of hepatopathies in veterinary medicine. However, the visual evaluation of fibrosis is usually limited by the observer's capabilities. This paper aimed to present the applicability of fractal anal...
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Veröffentlicht in: | Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine 2016-01, Vol.73 (1) |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The histopathologic examination of hepatic fibrosis remains the gold standard in routine diagnosis of hepatopathies in veterinary medicine. However, the visual evaluation of fibrosis is usually limited by the observer's capabilities. This paper aimed to present the applicability of fractal analysis as a quantitative method for evaluating the liver fibrosis grading using accessible tools, compared to one of the semiquantitative methods used currently in human histopathology, the METAVIR scoring system. Ovine liver histological sections taken from 22 slaughtered lambs, Masson's trichrome-stained, were analyzed using the METAVIR score as the semiquantitative method for staging the liver fibrosis and inflammatory reaction, and the fractal dimension of collagen regions as a quantitative method for fibrosis evaluation. The results show strong correlations between fibrosis and fractal dimension as the statistics revealed that there is a significant difference between the presence of fibrosis and its absence (p |
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ISSN: | 1843-5270 1843-5378 |
DOI: | 10.15835/buasvmcn-vm:11379 |