An Injectable, Self-Healing Hydrogel to Repair the Central Nervous System

An Injectable, Self-Healing Hydrogel to Repair the Central Nervous System

An injectable, self‐healing hydrogel (≈1.5 kPa) is developed for healing nerve‐system deficits. Neurosphere‐like progenitors proliferate in the hydrogel and differentiate into neuron‐like cells. In the zebrafish injury model, the central nervous system function is partially rescued by injection of t...

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Veröffentlicht in:Advanced materials (Weinheim) 2015-06, Vol.27 (23), p.3518-3524
Hauptverfasser: Tseng, Ting-Chen, Tao, Lei, Hsieh, Fu-Yu, Wei, Yen, Chiu, Ing-Ming, Hsu, Shan-hui
Format: Artikel
Sprache:eng
Schlagworte:
Alginates - chemistry
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Central nervous system
Central Nervous System - cytology
Central Nervous System - drug effects
Central Nervous System - injuries
Chitosan - chemistry
Danio rerio
Glucuronic Acid - chemistry
Healing
Hexuronic Acids - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology
Hydrogels
injectable hydrogels
Injections
Injuries
Mathematical models
Mechanical Phenomena
neural repair
neural stem cells
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Repair
self-healing polymers
Zebrafish
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Beschreibung
Zusammenfassung:An injectable, self‐healing hydrogel (≈1.5 kPa) is developed for healing nerve‐system deficits. Neurosphere‐like progenitors proliferate in the hydrogel and differentiate into neuron‐like cells. In the zebrafish injury model, the central nervous system function is partially rescued by injection of the hydrogel and significantly rescued by injection of the neurosphere‐laden hydrogel. The self‐healing hydrogel may thus potentially repair the central nervous system.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201500762