Effect of transtympanic betamethasone delivery to the inner ear

To investigate the effect of transtympanic betamethasone administration on hearing function with histologic correlation, rats were divided into three transtympanic treatment groups: isotonic saline (group I, n = 10), gentamicin (group II, n = 10) and betamethasone (group III, n = 10). Distortion...

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Veröffentlicht in:	European archives of oto-rhino-laryngology 2016-10, Vol.273 (10), p.3053-3061
Hauptverfasser:	Özel, Halil Erdem, Özdoğan, Fatih, Gülşen Gürgen, Seren, Esen, Erkan, Selçuk, Adin, Genç, Selahattin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Betamethasone - administration & dosage Caspase 3 - metabolism Caspase 8 - metabolism Cochlea - drug effects Cochlea - enzymology Ear, Inner - drug effects Ear, Inner - enzymology Ear, Inner - physiology Gentamicins - pharmacology Glucocorticoids - administration & dosage Hair Cells, Auditory, Outer - drug effects Head and Neck Surgery In Situ Nick-End Labeling Male Medicine Medicine & Public Health Neurosurgery Organ of Corti - drug effects Otoacoustic Emissions, Spontaneous - drug effects Otoacoustic Emissions, Spontaneous - physiology Otology Otorhinolaryngology Rats Rats, Wistar Sensory Thresholds - drug effects Sensory Thresholds - physiology Spiral Ganglion - drug effects Tympanic Membrane
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Zusammenfassung:	To investigate the effect of transtympanic betamethasone administration on hearing function with histologic correlation, rats were divided into three transtympanic treatment groups: isotonic saline (group I, n = 10), gentamicin (group II, n = 10) and betamethasone (group III, n = 10). Distortion product otoacoustic emission thresholds were compared on day 10. Also histological effects on cellular apoptosis in both the inner and outer hair cells in organ of Corti and spiral ganglion neurons were evaluated. Distortion product otoacoustic emission thresholds were comparable ( p > 0.05) between group I and group III in all measurements. Distortion product otoacoustic emission thresholds of group II were significantly elevated in all measurements when compared with group I ( p
ISSN:	0937-4477 1434-4726
DOI:	10.1007/s00405-016-3905-9