Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model

Highlights • Galleria mellonella is a useful model to evaluate infection by Paracoccidioides spp. and response to antifungals. • Fungicidal and fungistatic effects of amphotericin B and itraconazole, respectively, were observed in the model. • Antifungals did not affect the haemocyte density. • G. m...

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Veröffentlicht in:	International journal of antimicrobial agents 2016-09, Vol.48 (3), p.292-297
Hauptverfasser:	Singulani, Junya De Lacorte, Scorzoni, Liliana, De Paula E. Silva, Ana Carolina Alves, Fusco-Almeida, Ana Marisa, Mendes-Giannini, Maria José Soares
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative animal model Amphotericin B - administration & dosage Animals Antifungal Agents - administration & dosage Antifungals Colony Count, Microbial Disease Models, Animal Drug Evaluation, Preclinical - methods Efficacy Infectious Disease Itraconazole - administration & dosage Larva - microbiology Lepidoptera - microbiology Paracoccidioides - drug effects Paracoccidioidomycosis Paracoccidioidomycosis - drug therapy Paracoccidioidomycosis - microbiology Survival Analysis Treatment Outcome
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Zusammenfassung:	Highlights • Galleria mellonella is a useful model to evaluate infection by Paracoccidioides spp. and response to antifungals. • Fungicidal and fungistatic effects of amphotericin B and itraconazole, respectively, were observed in the model. • Antifungals did not affect the haemocyte density. • G. mellonella can serve as a rapid model to test other isolates of Paracoccidioides and can be used to screen new antifungal compounds against this fungi.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.05.012