Antimicrobial effects of Lactobacillus plantarum and Lactobacillus acidophilus against multidrug-resistant enteroaggregative Escherichia coli

Highlights • First study to evaluate antibacterial effect of probiotic strains against multidrug-resistant enteroaggregative Escherichia coli (MDR-EAEC). • In vitro, probiotic strains in synergy were more effective against MDR-EAEC. • Probiotic-treated mice cleared MDR-EAEC on Day 5 post-treatment....

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Veröffentlicht in:	International journal of antimicrobial agents 2016-09, Vol.48 (3), p.265-270
Hauptverfasser:	Kumar, Manesh, Dhaka, Pankaj, Vijay, Deepthi, Vergis, Jess, Mohan, Vysakh, Kumar, Ashok, Kurkure, Nitin V, Barbuddhe, Sukhadeo B, Malik, S.V.S, Rawool, Deepak B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibiosis Bacterial Load Colony Count, Microbial Drug resistance Enteroaggregative Escherichia coli Escherichia coli - physiology Escherichia coli Infections - microbiology Escherichia coli Infections - therapy Infectious Disease Lactobacillus acidophilus Lactobacillus acidophilus - physiology Lactobacillus plantarum Lactobacillus plantarum - physiology Male Mice Probiotics Probiotics - administration & dosage Real-Time Polymerase Chain Reaction Time Factors Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • First study to evaluate antibacterial effect of probiotic strains against multidrug-resistant enteroaggregative Escherichia coli (MDR-EAEC). • In vitro, probiotic strains in synergy were more effective against MDR-EAEC. • Probiotic-treated mice cleared MDR-EAEC on Day 5 post-treatment. • Histopathological changes were regenerative or normal in probiotic-treated mice. • Probiotics can serve as alternative therapeutics to curb MDR-EAEC infections.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.05.014