Dextran sulfate sodium-induced acute experimental colitis in C57BL/6 mice is mitigated by selenium

Sodium selenite has been shown to have a protective role in experimental colitis. Th1 and Th17 responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and inflammatory bowel disease. This study investigated whether sodium selenite can suppress Th1/Th17-mediated exp...

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Veröffentlicht in:	International immunopharmacology 2016-10, Vol.39, p.359-368
Hauptverfasser:	Sang, Lixuan, Chang, Bing, Zhu, Junfeng, Yang, Fangli, Li, Yan, Jiang, Xuefeng, Sun, Xun, Lu, Changlong, Wang, Danan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Colitis - chemically induced Colitis - drug therapy Colon - drug effects Colon - pathology Dextran Sulfate DSS-induced colitis Forkhead Transcription Factors - metabolism Humans Inflammatory bowel disease Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-17 - metabolism Male Mice Mice, Inbred C57BL Models, Animal Sodium selenite Sodium Selenite - therapeutic use T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Th17 Cells - immunology
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