INTRATRACHEAL THERAPY WITH AUTOLOGOUS BONE MARROW-DERIVED MONONUCLEAR CELLS REDUCES AIRWAY INFLAMMATION IN HORSES WITH RECURRENT AIRWAY OBSTRUCTION

Highlights • The cell therapy reduced the number of neutrophils in the BALF. • The cell therapy increased the number of macrophages in the BALF. • The cell therapy improved the clinical parameters of RAO horses. • The cell therapy increased the level of the anti-inflammatory interleukin-10. • Instil...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2016-10, Vol.232, p.35-42
Hauptverfasser:	Barussi, Fernanda C.M, Bastos, Fernanda Z, Leite, Lidiane M.B, Fragoso, Felipe Y.I, Senegaglia, Alexandra C, Brofman, Paulo R.S, Nishiyama, Anita, Pimpão, Cláudia T, Michelotto, Pedro V
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Obstruction - complications Airway Obstruction - surgery Airway Obstruction - veterinary Analysis of Variance Animals Bone Marrow Transplantation - methods Bronchoalveolar lavage Bronchoalveolar Lavage Fluid - microbiology Dexamethasone - therapeutic use Female Flow Cytometry Follow-Up Studies Heaves Horses Inflammation - complications Inflammation - surgery Inflammation - veterinary Injection, Intratympanic - methods Interleukin-10 - metabolism Interleukins Macrophages - physiology Male Medical Education Neutrophils Neutrophils - physiology Pulmonary inflammation Pulmonary/Respiratory Transplantation, Autologous
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Zusammenfassung:	Highlights • The cell therapy reduced the number of neutrophils in the BALF. • The cell therapy increased the number of macrophages in the BALF. • The cell therapy improved the clinical parameters of RAO horses. • The cell therapy increased the level of the anti-inflammatory interleukin-10. • Instillation of BMMCs can be a new treatment for horses with RAO.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2016.07.002