(S)-(−)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice

(S)-(−)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide.

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Bibliographische Detailangaben
Veröffentlicht in:	Anti-cancer drugs 2001-06, Vol.12 (5), p.453-458
Hauptverfasser:	Misiura, Konrad, Kinas, Ryszard W, Kus´nierczyk, Halina, Radzikowski, Czesłlaw, Stec, Wojciech J
Format:	Artikel
Sprache:	eng
Schlagworte:	(S)-(-)-bromofosfamide Animals Antineoplastic Agents, Alkylating - chemical synthesis Antineoplastic Agents, Alkylating - therapeutic use Biological Availability Carcinoma, Lewis Lung - drug therapy Chromatography, High Pressure Liquid Crosses, Genetic Female ifosfamide Ifosfamide - analogs & derivatives Ifosfamide - chemical synthesis Ifosfamide - therapeutic use Injections, Subcutaneous Leukemia L1210 - drug therapy Melanoma, Experimental - drug therapy Mice Mice, Inbred C57BL Mice, Inbred DBA Molecular Structure
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Beschreibung
Zusammenfassung:	(S)-(−)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide.
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-200106000-00006