A Library of Fluorinated Electrophiles for Chemical Tagging and Materials Synthesis

Various applications could benefit from new fluorinated molecules that offer chemical handles for quickly functionalizing reactive surfaces and molecules. Herein, we report the synthesis of a library of fluorinated molecules that contain nonafluoro-tert-butyl groups and electrophilic handles, mostly...

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Veröffentlicht in:Journal of organic chemistry 2016-09, Vol.81 (17), p.8095-8103
Hauptverfasser: Kasper, Jonathan J, Hitro, Jamie E, Fitzgerald, Sabrina R, Schnitter, Joseph M, Rutowski, James J, Heck, John A, Steinbacher, Jeremy L
Format: Artikel
Sprache:eng
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Zusammenfassung:Various applications could benefit from new fluorinated molecules that offer chemical handles for quickly functionalizing reactive surfaces and molecules. Herein, we report the synthesis of a library of fluorinated molecules that contain nonafluoro-tert-butyl groups and electrophilic handles, mostly acrylates and acrylamides. Featuring a variety of hydrophobic and hydrophilic linkers, these molecules could find use in polymer chemistry, biomaterials, biomedical imaging, and protein tagging.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b01572