Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats

Highlights • GL prevents oxidative stress after status epilepticus in the hippocampus and olfactory bulb. • Pretreatment with GL increases antioxidant enzyme activity in the hippocampus. • GL preserves enzyme activities in the olfactory bulb. • GL decreases inflammation in the hippocampus and olfact...

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Veröffentlicht in:	Epilepsy research 2016-10, Vol.126, p.126-133
Hauptverfasser:	González-Reyes, Susana, Santillán-Cigales, Juan Jair, Jiménez-Osorio, Angélica Saraí, Pedraza-Chaverri, José, Guevara-Guzmán, Rosalinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antioxidants - chemistry Antioxidants - pharmacology Disease Models, Animal Fluorometry Glycyrrhizic Acid - chemistry Glycyrrhizic Acid - pharmacology Glycyrrhizin Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Lithium Compounds Male Neurology Olfactory bulb Olfactory Bulb - drug effects Olfactory Bulb - metabolism Olfactory Bulb - pathology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Pilocarpine Rats, Wistar Status epilepticus Status Epilepticus - drug therapy Status Epilepticus - metabolism Status Epilepticus - pathology Stereoisomerism
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Zusammenfassung:	Highlights • GL prevents oxidative stress after status epilepticus in the hippocampus and olfactory bulb. • Pretreatment with GL increases antioxidant enzyme activity in the hippocampus. • GL preserves enzyme activities in the olfactory bulb. • GL decreases inflammation in the hippocampus and olfactory bulb after status epilepticus.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2016.07.007