Improved paclitaxel accumulation in cell suspension cultures of Taxus chinensis by brassinolide

When brassinolide was added at 17 ng l(-1) to Taxus chinensis cell suspension cultures, the paclitaxel content was increased by over 100% to 580 microgram g(-1) dry weight. Brassinolide may therefore be a novel regulator of paclitaxel biosynthesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Biotechnology letters 2001-01, Vol.23 (13), p.1047-1049
Hauptverfasser:	Zang, X, Mei, X.G, Zhang, C.H, Lu, C.T, Ke, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic drugs. Cytokines Biological and medical sciences Biosynthesis Biotechnology brassinolide Cell culture Chemotherapy Establishment of new cell lines, improvement of cultural methods, mass culture Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Medical sciences Methods. Procedures. Technologies paclitaxel Pharmacology. Drug treatments Plant cells and fungal cells Production of active biomolecules Taxus Taxus chinensis
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Beschreibung
Zusammenfassung:	When brassinolide was added at 17 ng l(-1) to Taxus chinensis cell suspension cultures, the paclitaxel content was increased by over 100% to 580 microgram g(-1) dry weight. Brassinolide may therefore be a novel regulator of paclitaxel biosynthesis.
ISSN:	0141-5492 1573-6776
DOI:	10.1023/A:1010589304749