Copper(I)-catalyzed domino allylic C(sp3)–H aminative cyclization/oxidative reaction and its application toward pyrrolo[3,4-d]pyrimidinones

Copper(I)-catalyzed domino allylic C(sp3)–H aminative cyclization/oxidative reaction and its application toward pyrrolo[3,4-d]pyrimidinones

An efficient tandem copper(I)-catalyzed intramolecular allylic C(sp3)–H functionalization/C–N formation/oxidative reaction of 6-methyl-dihydropyrimidine-2-one-5-carboxamides has been developed for the synthesis of substituted 2H-pyrrolo[3,4-d]pyrimidine-2,5,7(3H,6H)-trione derivatives in a single st...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron 2016-06, Vol.72 (22), p.3077-3083
Hauptverfasser: Zhang, Zhiguo, Yan, Xiangqian, Zhang, Guisheng, Liu, Qingfeng, Ma, Nana, Liu, Tongxin, Shi, Lei
Format: Artikel
Sprache:eng
Schlagworte:
C(sp3)–H functionalization
Copper-catalyzed
C–N formation
Derivatives
Formations
Pyrimidine derivatization
Pyrrolo[3,4-d]pyrimidinones
Synthesis (chemistry)
Tetrahedrons
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An efficient tandem copper(I)-catalyzed intramolecular allylic C(sp3)–H functionalization/C–N formation/oxidative reaction of 6-methyl-dihydropyrimidine-2-one-5-carboxamides has been developed for the synthesis of substituted 2H-pyrrolo[3,4-d]pyrimidine-2,5,7(3H,6H)-trione derivatives in a single step in good to excellent yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.04.031