Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells

Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells

Self-assembled micelles of amphiphilic PEG–rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational ther...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-01, Vol.3 (7), p.1204-1207
Hauptverfasser: Tian, Wei, Liu, Jieying, Guo, Yuan, Shen, Yuanyuan, Zhou, Dejian, Guo, Shengrong
Format: Artikel
Sprache:eng
Schlagworte:
Biology
Bypasses
Cancer
Chemistry
Conjugates
Human
Micelles
Nanostructure
Rapamycin
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Zusammenfassung:Self-assembled micelles of amphiphilic PEG–rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell.
ISSN:2050-750X
2050-7518
DOI:10.1039/C4TB01633E