Gold-Catalyzed Aminoalkenylation of β-Amino-1,n-Diynols to Cycloalkyl-, Piperidinyl- and Pyranyl-Fused Pyrroles

Gold-Catalyzed Aminoalkenylation of β-Amino-1,n-Diynols to Cycloalkyl-, Piperidinyl- and Pyranyl-Fused Pyrroles

A synthetic method to prepare cycloalkyl‐, piperidinyl‐ and pyranyl‐fused pyrroles efficiently by gold(I)‐catalyzed dehydrative aminoalkenylation of β‐amino‐1,n‐diynols under mild conditions at room temperature is described.

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Veröffentlicht in:Advanced synthesis & catalysis 2016-04, Vol.358 (9), p.1385-1391
Hauptverfasser: Kothandaraman, Prasath, Zhao, Yichao, Lee, Bo Ra, Le Ng, Clarrisa Jia, Lee, Jun Yi, Ayers, Benjamin James, Chan, Philip Wai Hong
Format: Artikel
Sprache:eng
Schlagworte:
1,2-amino alcohols
2-amino alcohols
Catalysis
Dehydration
gold
homogeneous catalysis
nitrogen heterocycles
Pyrroles
Synthesis
synthetic methods
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Zusammenfassung:A synthetic method to prepare cycloalkyl‐, piperidinyl‐ and pyranyl‐fused pyrroles efficiently by gold(I)‐catalyzed dehydrative aminoalkenylation of β‐amino‐1,n‐diynols under mild conditions at room temperature is described.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600011