Rhodium-Catalyzed Tandem Annulation Reactions of 7-Azaindoles with Electron-Deficient Olefins via Double CH Activation

Rhodium-Catalyzed Tandem Annulation Reactions of 7-Azaindoles with Electron-Deficient Olefins via Double CH Activation

Rhodium‐catalyzed tandem annulation reactions via olefination and subsequent intramolecular C‐Michael‐type cyclization represent an efficient approach for the direct construction of CC bonds. The simple and atom‐economic strategy produces various alkylation derivatives of 7‐azaindole with a quatern...

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Veröffentlicht in:Advanced synthesis & catalysis 2016-05, Vol.358 (10), p.1595-1601
Hauptverfasser: Li, Shuai-Shuai, Lin, Hui, Liu, Chen-Fei, Xia, Ying-Qi, Zhang, Xiao-Mei, Dong, Lin
Format: Artikel
Sprache:eng
Schlagworte:
7-azaindoles
C-Michael cyclization
Carbon
Catalysis
Chemical reactions
CH activation
Derivatives
electron-deficient alkenes
Olefins
Organic chemistry
Rhodium
Strategy
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Zusammenfassung:Rhodium‐catalyzed tandem annulation reactions via olefination and subsequent intramolecular C‐Michael‐type cyclization represent an efficient approach for the direct construction of CC bonds. The simple and atom‐economic strategy produces various alkylation derivatives of 7‐azaindole with a quaternary carbon center from 7‐azaindoles and olefins.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600112