Synthesis of highly functionalized 2-thiaspiro[4.5]deca-6,8-dienes via atom efficient tandem Michael addition/Thorpe–Ziegler cyclization

Synthesis of highly functionalized 2-thiaspiro[4.5]deca-6,8-dienes via atom efficient tandem Michael addition/Thorpe–Ziegler cyclization

The two-component reaction of 2,4-bis(( Z )-arylidene)dihydrothiophen-3(2 H )-ones and 2-(1-arylethylidene)malononitriles proceeded through a tandem chemoselective Michael addition–tautomerization–Thorpe–Ziegler cyclization sequence of reactions in a single step affording novel 2-thiaspiro[4.5]deca-...

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Veröffentlicht in:RSC advances 2016-01, Vol.6 (46), p.40585-40592
Hauptverfasser: Rani, Mani Anusha, Kumar, Sundaravel Vivek, Roja, Somi Santharam, Almansour, Abdulrahman I., Kumar, Raju Suresh, Athimoolam, S., Kumar, Raju Ranjith
Format: Artikel
Sprache:eng
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Synthesis
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Zusammenfassung:The two-component reaction of 2,4-bis(( Z )-arylidene)dihydrothiophen-3(2 H )-ones and 2-(1-arylethylidene)malononitriles proceeded through a tandem chemoselective Michael addition–tautomerization–Thorpe–Ziegler cyclization sequence of reactions in a single step affording novel 2-thiaspiro[4.5]deca-6,8-dienes in quantitative yields.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA05572A