Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array
Heterogeneous 3D cell microenvironment arrays are rapidly assembled by combining surface‐wettability‐guided assembly and microdroplet‐array‐based operations. This approach enables precise control over individual shapes, sizes, chemical concentrations, cell density, and 3D spatial distribution of mul...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2016-05, Vol.28 (18), p.3543-3548 |
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| container_title | Advanced materials (Weinheim) |
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| creator | Li, Yiwei Chen, Pu Wang, Yachao Yan, Shuangqian Feng, Xiaojun Du, Wei Koehler, Stephan A. Demirci, Utkan Liu, Bi-Feng |
| description | Heterogeneous 3D cell microenvironment arrays are rapidly assembled by combining surface‐wettability‐guided assembly and microdroplet‐array‐based operations. This approach enables precise control over individual shapes, sizes, chemical concentrations, cell density, and 3D spatial distribution of multiple components. This technique provides a cost‐effective solution to meet the increasing demand of stem cell research, tissue engineering, and drug screening. |
| doi_str_mv | 10.1002/adma.201600247 |
| format | Article |
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This approach enables precise control over individual shapes, sizes, chemical concentrations, cell density, and 3D spatial distribution of multiple components. This technique provides a cost‐effective solution to meet the increasing demand of stem cell research, tissue engineering, and drug screening.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201600247</identifier><identifier>PMID: 26991071</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Arrays ; Assembly ; cell microenvironment ; Density ; heterogeneous microenvironment arrays ; microgel assembly ; Screening ; Spatial distribution ; Stem cells ; Three dimensional ; Tissue engineering</subject><ispartof>Advanced materials (Weinheim), 2016-05, Vol.28 (18), p.3543-3548</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. 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This technique provides a cost‐effective solution to meet the increasing demand of stem cell research, tissue engineering, and drug screening.</description><subject>Arrays</subject><subject>Assembly</subject><subject>cell microenvironment</subject><subject>Density</subject><subject>heterogeneous microenvironment arrays</subject><subject>microgel assembly</subject><subject>Screening</subject><subject>Spatial distribution</subject><subject>Stem cells</subject><subject>Three dimensional</subject><subject>Tissue engineering</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkE1P20AQhldVURPSXjmiPfbiMOv98h6tpAWkBBCl4rha2-PI4I90N2nJv8fBEPWW02hHz_tq9iHkjMGUAcQXrmjcNAam-ofQn8iYyZhFAoz8TMZguIyMEsmInIbwBABGgfpCRrEyhoFmY7K8d-uqoGkI2GT1jnYlvcIN-m6FLXbbQPmczrCu6bLKfYft38p3bYPtJtCqpW5Yr7Cmqfdu95WclK4O-O19Tsjvnz8eZlfR4vbyepYuolxIriNZKq4VaJNhlkGsBdPMmNhkskRWcOnyHAXDhJdxDtJJnvNCscxIJU3Cc8Mn5PvQu_bdny2GjW2qkPdnurejLUt6ISzRiTqO6kQLzUEkPTod0P5LIXgs7dpXjfM7y8Dubdu9bXuw3QfO37u3WYPFAf_Q2wNmAP5VNe6O1Nl0vkz_L4-GbBU2-HLIOv9sleZa2sebS_sL5uLhTjD7yF8BSVKYpQ</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Li, Yiwei</creator><creator>Chen, Pu</creator><creator>Wang, Yachao</creator><creator>Yan, Shuangqian</creator><creator>Feng, Xiaojun</creator><creator>Du, Wei</creator><creator>Koehler, Stephan A.</creator><creator>Demirci, Utkan</creator><creator>Liu, Bi-Feng</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>201605</creationdate><title>Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array</title><author>Li, Yiwei ; Chen, Pu ; Wang, Yachao ; Yan, Shuangqian ; Feng, Xiaojun ; Du, Wei ; Koehler, Stephan A. ; Demirci, Utkan ; Liu, Bi-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4537-5f6376079bebb02741719929b5fe1d35acce41e83f2c05a53c3d61b9565983c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Arrays</topic><topic>Assembly</topic><topic>cell microenvironment</topic><topic>Density</topic><topic>heterogeneous microenvironment arrays</topic><topic>microgel assembly</topic><topic>Screening</topic><topic>Spatial distribution</topic><topic>Stem cells</topic><topic>Three dimensional</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yiwei</creatorcontrib><creatorcontrib>Chen, Pu</creatorcontrib><creatorcontrib>Wang, Yachao</creatorcontrib><creatorcontrib>Yan, Shuangqian</creatorcontrib><creatorcontrib>Feng, Xiaojun</creatorcontrib><creatorcontrib>Du, Wei</creatorcontrib><creatorcontrib>Koehler, Stephan A.</creatorcontrib><creatorcontrib>Demirci, Utkan</creatorcontrib><creatorcontrib>Liu, Bi-Feng</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yiwei</au><au>Chen, Pu</au><au>Wang, Yachao</au><au>Yan, Shuangqian</au><au>Feng, Xiaojun</au><au>Du, Wei</au><au>Koehler, Stephan A.</au><au>Demirci, Utkan</au><au>Liu, Bi-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. 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| identifier | ISSN: 0935-9648 |
| ispartof | Advanced materials (Weinheim), 2016-05, Vol.28 (18), p.3543-3548 |
| issn | 0935-9648 1521-4095 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1816018786 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Arrays Assembly cell microenvironment Density heterogeneous microenvironment arrays microgel assembly Screening Spatial distribution Stem cells Three dimensional Tissue engineering |
| title | Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array |
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