A de novoself-assembling peptide hydrogel biosensor with covalently immobilised DNA-recognising motifs

A de novoself-assembling peptide hydrogel biosensor with covalently immobilised DNA-recognising motifs

We report here the first experimental evidence of a self-assembling three-dimensional (3D) peptide hydrogel, with recognition motifs immobilized on the surface of fibres capable of sequence-specific oligonucleotide detection. These systems have the potential to be further developed into diagnostic a...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-05, Vol.52 (40), p.6697-6700
Hauptverfasser: King, Patrick JS, Saiani, Alberto, Bichenkova, Elena V, Miller, Aline F
Format: Artikel
Sprache:eng
Schlagworte:
Covalence
Fibres
Human
Hydrogels
Oligonucleotides
Peptides
Recognition
Three dimensional
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Beschreibung
Zusammenfassung:We report here the first experimental evidence of a self-assembling three-dimensional (3D) peptide hydrogel, with recognition motifs immobilized on the surface of fibres capable of sequence-specific oligonucleotide detection. These systems have the potential to be further developed into diagnostic and prognostic tools in human pathophysiology.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc01433j