Cranial bone collapse in microcephalic infants prenatally exposed to Zika virus infection

Brazil has been experiencing an outbreak of Zika virus, a flavivirus transmitted by Aedes mosquitoes. Since October 2015, more than 4,000 infants,[1] born to mothers suspected to have contracted this infection during pregnancy, have microcephaly[1,2] and CNS malformations (figure 1), including parenchymal and periventricular calcifications, ventriculomegaly, and cortical migration anomalies.2 This suggests marked viral neurotropism. Upon performing CT, cranial malformations (figure 2) with a pointed occiput are also observed.