Association of HLA-DR/DQ alleles and haplotypes with nephrotic syndrome

Background Nephrotic syndrome (NS) is a debilitating renal problem in children resulting from an interaction between environmental and genetic factors including human leukocyte antigen genes (HLA). The aim of this work was to study the probable link between HLA alleles/haplotypes and NS in south Ind...

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Veröffentlicht in:	Nephrology (Carlton, Vic.) Vic.), 2016-09, Vol.21 (9), p.745-752
Hauptverfasser:	Ramanathan, Aravind Selvin Kumar, Senguttuvan, Prabha, Chinniah, Rathika, Vijayan, Murali, Thirunavukkarasu, Manikandan, Raju, Kamaraj, Mani, Dhivakar, Ravi, Padma Malini, Rajendran, Padmaraj, Krishnan, Jeyaram Illiayaraja, Karuppiah, Balakrishnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Case-Control Studies Child Child, Preschool Extended haplotype Female focal segmental glomerulosclerosis Gene Frequency Genetic Association Studies Genetic Markers Genetic Predisposition to Disease Glomerulosclerosis, Focal Segmental - diagnosis Glomerulosclerosis, Focal Segmental - drug therapy Glomerulosclerosis, Focal Segmental - genetics Glomerulosclerosis, Focal Segmental - immunology Glucocorticoids - therapeutic use Haplotypes HLA-DQ beta-Chains - genetics HLA-DQ beta-Chains - immunology HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology human leukocyte antigen Humans India Male Nephrosis, Lipoid - diagnosis Nephrosis, Lipoid - drug therapy Nephrosis, Lipoid - genetics Nephrosis, Lipoid - immunology nephrotic syndrome Nephrotic Syndrome - congenital Nephrotic Syndrome - diagnosis Nephrotic Syndrome - drug therapy Nephrotic Syndrome - genetics Nephrotic Syndrome - immunology Phenotype Polymerase Chain Reaction Prednisolone - therapeutic use Remission Induction Risk Factors Sex Factors south Indian children steroid resistant nephrotic syndrome Treatment Outcome
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Zusammenfassung:	Background Nephrotic syndrome (NS) is a debilitating renal problem in children resulting from an interaction between environmental and genetic factors including human leukocyte antigen genes (HLA). The aim of this work was to study the probable link between HLA alleles/haplotypes and NS in south India. Methods HLA DRB1/DQB1 alleles were genotyped in 183 NS (76 steroid sensitive‐SSNS; 107 steroid resistant‐SRNS) and paediatric healthy controls (PHCs; n = 91) using polymerase chain reaction‐sequence specific primers (PCR‐SSP). HLA‐A/‐B genotyping was performed for patients (n = 70) positive for DRB107‐DQB102 haplotype to identify four locus extended haplotype. Results The following alleles and haplotypes were strongly associated with NS (P
ISSN:	1320-5358 1440-1797
DOI:	10.1111/nep.12669