Comparisons of GFR estimation using the CKD Epidemiology Collaboration (CKD-EPI) equation and other creatinine-based equations in Asian population: a systematic review

Purpose The aim of the study was to summarize the evidence of the validation of CKD-EPI equation and alternative creatinine-based equations in Asian population. Methods Relevant validation studies of CKD-EPI and other creatinine-based equations were identified by a systematic literature searching of PubMed conducted from January 2009 through August 2014. Searching terms included “CKD EPI”, “Kidney function test [MeSH] and validation”, and “Glomerular filtration rate [MeSH] and validation” without language or design of study restrictions. The quality of each study was assessed using Quality Assessment of diagnostic Accuracy studies-2 tool. Results Of 1064 studies identified, 10 studies were included in the present systematically review. The CKD-EPI equation has been validated in several Asian population including Thai, Japanese, Chinese, Taiwanese, Pakistani as well as Arabic. CKD-EPI equation met the clinically significant 75 % P30 value in several populations, although corrections of some factors may increase the accuracy of the equation. However, some populations may need to find more accurate equations or methods to estimate GFR for the patients. Conclusions CKD-EPI is a good equation to start with for estimation of patients’ renal function but for certain disease states and racial populations, the CKD-EPI should be validated before applying. More research is needed in order to develop validated eGFR equations for specific populations and to improve upon the accuracies of currently acceptable equations to better guide therapy and improve patient outcomes.