Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

The ebolavirus immunotherapeutics field has replaced previous perceptions of antibody inadequacy with a new abundance of monoclonals exhibiting post exposure efficacy. Now the questions are: what epitopes to target, what immunological mechanisms to seek, whether species-specific or broadly reactive...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in microbiology (Regular ed.) 2016-09, Vol.24 (9), p.684-686
Hauptverfasser:	Saphire, Erica Ollmann, Aman, M. Javad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Antibodies, Viral - immunology Antibodies, Viral - therapeutic use Ebolavirus - immunology Epitopes - immunology Hemorrhagic Fever, Ebola - therapy Hemorrhagic Fever, Ebola - virology Humans Immunotherapy - methods Internal Medicine Mice Viral Envelope Proteins - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The ebolavirus immunotherapeutics field has replaced previous perceptions of antibody inadequacy with a new abundance of monoclonals exhibiting post exposure efficacy. Now the questions are: what epitopes to target, what immunological mechanisms to seek, whether species-specific or broadly reactive antibodies are best, and whether a cocktail or monotherapy should be used.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2016.05.008