Predictive value of maternal serum NF-κB p65 and sTREM-1 for subclinical chorioamnionitis in premature rupture of membranes

Problem The aim of this study was to investigate the levels of nuclear factor kappa B‐p65 (NF‐κB p65) and soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1) in maternal blood with premature rupture of membranes (PROM) and to assess their values for prediction of subclinical chorioamnionitis. Method NF‐κB p65 and sTREM‐1 levels were measured in maternal blood and cord blood by fluorescence quantitative RT‐PCR assay. According to the placental membranes pathological examination, pregnant women with PROM were divided into chorioamnionitis group (n=28) and non‐chorioamnionitis group (n=22). Results In the PROM group,the NF‐κB p65 and sTREM‐1 levels in maternal blood were significantly higher in women with chorioamnionitis than women without chorioamnionitis (P