Recent innovations in mRNA vaccines

Recent innovations in mRNA vaccines

Highlights • mRNA vaccines continue to show promise as prophylactic and therapeutic vaccines. • Clinical data with mRNA cancer vaccines indicate they are tolerated and immunogenic. • Self-amplifying mRNA vaccine are potent in larger animal at low doses (50 μg). • A broader package of human clinical...

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Veröffentlicht in:Current opinion in immunology 2016-08, Vol.41, p.18-22
Hauptverfasser: Ulmer, Jeffrey B, Geall, Andrew J
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Humans
RNA, Messenger - genetics
Vaccines, DNA - genetics
Vaccines, DNA - immunology
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Beschreibung
Zusammenfassung:Highlights • mRNA vaccines continue to show promise as prophylactic and therapeutic vaccines. • Clinical data with mRNA cancer vaccines indicate they are tolerated and immunogenic. • Self-amplifying mRNA vaccine are potent in larger animal at low doses (50 μg). • A broader package of human clinical proof of principle still needs to be developed.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.05.008