Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia

The neuroprotective effect of ubiquinone (coenzyme Q 10 )was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q 10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-06, Vol.161 (2), p.245-247
Hauptverfasser:	Belousova, M. A., Tokareva, O. G., Gorodetskaya, E. A., Kalenikova, E. I., Medvedev, O. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants (Nutrients) Biomedical and Life Sciences Biomedicine Cell Biology Disease Models, Animal Drug Evaluation, Preclinical Enzymes Free Radical Scavengers - administration & dosage Infarction, Middle Cerebral Artery - drug therapy Injections, Intravenous Internal Medicine Ischemia Laboratory Medicine Male Neuroprotective Agents - administration & dosage Pathology Pharmacology and Toxicology Physiological aspects Rats, Wistar Ubiquinone - administration & dosage Ubiquinone - analogs & derivatives
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Zusammenfassung:	The neuroprotective effect of ubiquinone (coenzyme Q 10 )was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q 10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3387-1