Viral vectors as vaccine platforms: from immunogenicity to impact

Highlights • Safety and potency of simian adenovirus vectors is now well established, most recently in infants. • Viral vectored vaccines are effective against malaria and Ebola in field trials. • Protective mechanisms involve both CD8+ T cells and neutralising antibodies. • Vaccine manufacture is s...

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Veröffentlicht in:	Current opinion in immunology 2016-08, Vol.41, p.47-54
Hauptverfasser:	Ewer, Katie J, Lambe, Teresa, Rollier, Christine S, Spencer, Alexandra J, Hill, Adrian VS, Dorrell, Lucy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Allergy and Immunology Animals Ebolavirus Genetic Vectors - genetics Human adenovirus Humans Immunogenicity, Vaccine - genetics Immunogenicity, Vaccine - immunology Viral Vaccines - genetics Viral Vaccines - immunology
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Beschreibung
Zusammenfassung:	Highlights • Safety and potency of simian adenovirus vectors is now well established, most recently in infants. • Viral vectored vaccines are effective against malaria and Ebola in field trials. • Protective mechanisms involve both CD8+ T cells and neutralising antibodies. • Vaccine manufacture is sufficiently scalable to enable a rapid response to outbreaks.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2016.05.014