CREBRF variant increases obesity risk and protects against diabetes in Samoans

CREBRF variant increases obesity risk and protects against diabetes in Samoans

A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but e...

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Veröffentlicht in:Nature genetics 2016-09, Vol.48 (9), p.976-978
1. Verfasser: Loos, Ruth J F
Format: Artikel
Sprache:eng
Schlagworte:
631/208/205/2138
692/699/1702/393
Adipocytes
Agriculture
Animal Genetics and Genomics
Biomedicine
Body mass index
Cancer Research
Consortia
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2
Gene Function
Genetic aspects
Genetic variation
Genome-Wide Association Study
Genomes
Health aspects
Human Genetics
Humans
Hypotheses
news-and-views
Obesity
Polymorphism, Single Nucleotide
Predation
Risk Factors
Risk reduction
Samoans
Studies
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Beschreibung
Zusammenfassung:A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but extremely rare in other populations, promotes fat storage and reduces energy use in cellular models.
ISSN:1061-4036
1546-1718
DOI:10.1038/ng.3653