Complete Myeloperoxidase Deficiency: Beware the “False-Positive” Dihydrorhodamine Oxidation

Myeloperoxidase deficiency is the most common inherited phagocyte disorder (1:2000) and causes an abnormal dihydrorhodamine oxidation test, which also is seen in chronic granulomatous disease. A patient with Candida meningitis and low dihydrorhodamine oxidation signal was diagnosed with chronic gran...

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Veröffentlicht in:	The Journal of pediatrics 2016-09, Vol.176, p.204-206
Hauptverfasser:	Milligan, Ki Lee, MD, Mann, Daphne, BSN, Rump, Amy, MSN, CRNP, Anderson, Victoria L., MSN, CRNP, Hsu, Amy P., BA, Kuhns, Douglas B., PhD, Zerbe, Christa S., MD, Holland, Steven M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	candida chronic granulomatous disease Diagnosis, Differential dihydrorhodamine False Positive Reactions Granulomatous Disease, Chronic - diagnosis Humans Male Metabolism, Inborn Errors - diagnosis myeloperoxidase deficiency neutrophil Oxidation-Reduction Pediatrics Rhodamines - metabolism Young Adult
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Beschreibung
Zusammenfassung:	Myeloperoxidase deficiency is the most common inherited phagocyte disorder (1:2000) and causes an abnormal dihydrorhodamine oxidation test, which also is seen in chronic granulomatous disease. A patient with Candida meningitis and low dihydrorhodamine oxidation signal was diagnosed with chronic granulomatous disease but actually had compound heterozygous myeloperoxidase deficiency.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2016.05.047