Comparison of solvent⿿wetted and kneaded l-sulpiride⿿loaded solid dispersions: Powder characterization and in vivo evaluation

[Display omitted] The purpose of this study was to compare the powder properties, solubility, dissolution and oral absorption of solvent⿿wetted (SWSD) and kneaded (KNSD) l-sulpiride⿿loaded solid dispersions. The SWSD and KNSD were prepared with silicon dioxide, sodium laurylsulfate and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) using a spray dryer and high shear mixer, respectively. Their powder properties, solubility, dissolution and oral absorption were assessed compared to l-sulpiride powder. The drug in SWSD was in the amorphous state; however, in KNSD, it existed in the crystalline state. The SWSD with a drug/sodium laurylsulphate/TPGS/silicon dioxide ratio of 5/1/2/12 gave the higher drug solubility and dissolution compared to the KNSD with the same composition. The oral absorption of drug in the SWSD was 1.4 fold higher than the KNSD and 3.0 fold higher than the l-sulpiride powder (p