Membrane localization and topology of the DnpA protein control fluoroquinolone tolerance in Pseudomonas aeruginosa

DnpA, a putative de-N-acetylase of the PIG-L superfamily, is required for antibiotic tolerance in Pseudomonas aeruginosa. Exactly how dnpA (gene locus PA5002) directs the formation of antibiotic-tolerant persister cells is currently unknown. Previous research provided evidence for a role in surface-...

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Veröffentlicht in:	FEMS microbiology letters 2016-09, Vol.363 (17), p.fnw184
Hauptverfasser:	Liebens, Veerle, Frangipani, Emanuela, Van der Leyden, Annelies, Fauvart, Maarten, Visca, Paolo, Michiels, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotic tolerance Antibiotics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioinformatics Biosynthesis Cell Membrane - chemistry Cell Membrane - metabolism Computer Simulation Fluoroquinolones - metabolism Fluoroquinolones - pharmacology Lipopolysaccharides Lipopolysaccharides - metabolism Localization Membrane proteins Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Microbiology Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Sequence analysis Topology Transmembrane domains
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