Gastrointestinal perforations in patients treated with erlotinib: A report of two cases with fatal outcome and literature review

Highlights • Two cases of gastrointestinal perforation (GIP), induced by erlotinib. • Only 1 case of erlotinib-associated GIP under monotherapy reported in the literature. • Risk factors: corticosteroids, medications modifying erlotinib metabolism, diarrhea.

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-09, Vol.99, p.76-78
Hauptverfasser:	Gass-Jégu, Florence, Gschwend, Anthony, Gairard-Dory, Anne-Cécile, Mennecier, Bertrand, Tebacher-Alt, Martine, Gourieux, Bénédicte, Quoix, Élisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse drug reaction Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Carcinoma, Non-Small-Cell Lung - complications Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Erlotinib Erlotinib Hydrochloride - adverse effects Erlotinib Hydrochloride - therapeutic use Fatal Outcome Gastrointestinal perforation Hematology, Oncology and Palliative Medicine Humans Intestinal Perforation - diagnosis Intestinal Perforation - etiology Intestinal Perforation - therapy Lung Neoplasms - complications Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Male Middle Aged Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pulmonary/Respiratory Radiography, Thoracic Stomach Diseases - diagnosis Stomach Diseases - etiology Stomach Diseases - therapy Tomography, X-Ray Computed
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Beschreibung
Zusammenfassung:	Highlights • Two cases of gastrointestinal perforation (GIP), induced by erlotinib. • Only 1 case of erlotinib-associated GIP under monotherapy reported in the literature. • Risk factors: corticosteroids, medications modifying erlotinib metabolism, diarrhea.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.06.012